Synergistic Gentamicin for Endocarditis in Adults (426)


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ALL patients with suspected or proven infective endocarditis (IE) should be discussed with microbiology or Infectious Diseases (ID) within 72 hours of starting antibiotic therapy AND re-discussed after 2 weeks if continuation of gentamicin is being considered.

Synergistic gentamicin is recommended in the initial empirical treatment of endocarditis and for some particular endocarditis pathogens, in accordance with national guidelines. When treating a patient with IE remember to consider resistance, clinical response, toxicity and suitability for outpatient parenteral antibiotic therapy (OPAT).


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Acute / All Inpatient

Last reviewed: 30 November 2019

Next review: 30 November 2022

Author(s): Ysobel Gourlay

Version: 3

Author Email(s): [email protected]

Approved By: Antimicrobial Utilisation Committee Important

Document Id: 426