Prostate Gold Seed Marker Insertion for Prostate Radiotherapy, Antibiotic Prophylaxis (898)


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A guideline is intended to assist healthcare professionals in the choice of disease-specific treatments.

Clinical judgement should be exercised on the applicability of any guideline, influenced by individual patient characteristics. Clinicians should be mindful of the potential for harmful polypharmacy and increased susceptibility to adverse drug reactions in patients with multiple morbidities or frailty.

If, after discussion with the patient or carer, there are good reasons for not following a guideline, it is good practice to record these and communicate them to others involved in the care of the patient.


Single dose of oral antibiotic.

MRSA: decolonise prior to procedure as per NHS GGC infection control guidelines and discuss with microbiology re antibiotic choice.

CPE carriers: For those patients who have been identified as CPE (carbapenemase producing enterobacteriaceae) carriers, contact microbiology

Table: Procedure > Recommended Antibiotic

Procedure Recommended antibiotic regimen Comments
Prostate Gold Seeds Marker Insertion for Prostate Radiotherapy Oral Ciprofloxacin 750mg
or If true ciprofloxacin/ quinolone allergy or contra-indications/ serious drug interactions
Oral Co-trimoxazole 960mg

Ciprofloxacin 30 minutes before skin incision/ intervention.

Co-trimoxazole 60 minutes before skin incision/ intervention

Last reviewed: 17 November 2020

Next review: 30 November 2023

Author(s): Ysobel Gourlay

Version: 1

Author Email(s): [email protected]

Approved By: Antimicrobial Utilisation Committee

Document Id: 898