Flucloxacillin is a beta-lactam antibiotic and the treatment choice for suspected or confirmed Staphylococcus aureus infective endocarditis. Clinical efficacy of beta-lactam antibiotics corresponds with time (T) the free drug exceeds the minimum inhibitory concentration (MIC) of the organism (T > MIC). Administration of flucloxacillin by continuous infusion may therefore be associated with better clinical outcomes when compared with intermittent infusions especially in critically ill patients. This method of administration also reduces nursing time spent preparing and administering this antibiotic, reduces the risk of missed doses and minimises the interruption for patients during unsociable hours (midnight – 6am).
If considering continuous infusion flucloxacillin please ensure:
- intravenous access is available 24 hours/ day
- infusion pump is available 24 hours/ day
- patient is not leaving the ward for extended periods of time
- renal function; Creatinine Clearance ≥ 30 ml/min
- history of true beta-lactam allergy or any excipients
- renal function; Creatinine Clearance < 30 ml/min