Ectopic Pregnancy Medical Management, Obstetrics and Gynaecology

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Methotrexate (for ectopic pregnancy)

Antimetabolite and antifolate drug which is an established, effective and safe treatment for unruptured ectopic pregnancy and treatment of PUL.

Success rates are around 80-90%.

Careful patient selection is paramount- consultant review is required.

Avoid aspirin or anti inflammatory drugs for 1 week after administration.

Avoid alcohol, vitamins containing folic acid, intercourse, and travel out with the local area until follow up is complete.

The vast majority of patients who have methotrexate will go on to have a subsequent intra-uterine pregnancy.

NOTE: this guideline is hosted on the NHSGGC Obstetrics & Gynaecology Handbook website. Clicking on the link below will open the guideline in a new window.


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